| Pair Name | Costunolide, Imatinib | ||
| Phytochemical Name | Costunolide (PubChem CID: 5281437 ) | ||
| Anticancer drug Name | Imatinib (PubChem CID: 123596 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Costunolide, Imatinib | |||
| Disease Info | [ICD-11: 2B33.3] | Acute lymphoblastic leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| In Vitro Model | K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 |
| Result | These results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway. Phytother Res. 2018 Sep;32(9):1764-1769. doi: 10.1002/ptr.6106. | Click |
